Drug interactions
Dapagliflozin + Insulin glargine
Severity: Moderate
Dapagliflozin and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin adds to insulin's glucose-lowering effect and increases the risk of hypoglycemia. Insulin dose reduction too far can contribute to ketoacidosis.
What this interaction means in plain words
Dapagliflozin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin plus insulin-independent glucosuria via SGLT2 inhibition.
What to do
Consider reducing the insulin dose when starting dapagliflozin and monitor glucose; check for ketoacidosis symptoms if unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin and Insulin glargine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin glargine
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin glargine?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin adds to insulin's glucose-lowering effect and increases the risk of hypoglycemia. Insulin dose reduction too far can contribute to ketoacidosis.
How serious is the interaction between Dapagliflozin and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting dapagliflozin and monitor glucose; check for ketoacidosis symptoms if unwell.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
