Drug interactions
Dapagliflozin + Letermovir
Severity: Minor
Dapagliflozin and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir may increase dapagliflozin exposure, possibly through inhibition of UGT1A1, its main metabolic pathway. Higher exposure could enhance glucose-lowering and volume-related effects, though the change is likely modest.
What this interaction means in plain words
Dapagliflozin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin belongs to Endocrine; Letermovir belongs to Anti Virals.
Why it happens
Letermovir may inhibit UGT1A1-mediated glucuronidation of dapagliflozin; the mechanism is not firmly established.
What to do
No dose change is usually required. Monitor blood glucose and hydration status during co-treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Dapagliflozin with Letermovir?
MediHelp rates the interaction as minor. Dapagliflozin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir may increase dapagliflozin exposure, possibly through inhibition of UGT1A1, its main metabolic pathway. Higher exposure could enhance glucose-lowering and volume-related effects, though the change is likely modest.
How serious is the interaction between Dapagliflozin and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor blood glucose and hydration status during co-treatment.
What other medicines interact with Dapagliflozin?
MediHelp also lists interactions of Dapagliflozin with, for example, Chlorpropamide, Gliclazide, Glimepiride. The full list is on the Dapagliflozin page.
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