Drug interactions
Dapagliflozin-metformin + Digoxin
Severity: Minor
Dapagliflozin-metformin and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may compete for renal tubular elimination, so exposure to either could rise modestly. Reports of clinically significant digoxin toxicity or lactic acidosis are limited, but patients with renal impairment are most at risk.
What this interaction means in plain words
Dapagliflozin-metformin and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Digoxin belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion via shared transporters.
What to do
Monitor serum digoxin levels and renal function when starting metformin, and watch for signs of digoxin toxicity. Adjust the dose of digoxin if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Digoxin?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs may compete for renal tubular elimination, so exposure to either could rise modestly. Reports of clinically significant digoxin toxicity or lactic acidosis are limited, but patients with renal impairment are most at risk.
How serious is the interaction between Dapagliflozin-metformin and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and renal function when starting metformin, and watch for signs of digoxin toxicity. Adjust the dose of digoxin if needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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