Drug interactions
Dapagliflozin-metformin + Estradiol
Severity: Minor
Dapagliflozin-metformin and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen therapy may alter glucose tolerance and insulin sensitivity, and in some patients may slightly reduce the effect of antidiabetic drugs. The effect is generally small and depends on dose and route.
What this interaction means in plain words
Dapagliflozin-metformin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Estradiol belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through variable effects of estrogens on insulin sensitivity.
What to do
Monitor glucose control when starting, stopping or changing estradiol therapy and adjust antidiabetic treatment if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Estradiol?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen therapy may alter glucose tolerance and insulin sensitivity, and in some patients may slightly reduce the effect of antidiabetic drugs. The effect is generally small and depends on dose and route.
How serious is the interaction between Dapagliflozin-metformin and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control when starting, stopping or changing estradiol therapy and adjust antidiabetic treatment if needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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