Drug interactions
Dapagliflozin-metformin + Everolimus
Severity: Moderate
Dapagliflozin-metformin and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus commonly causes hyperglycemia and dyslipidemia, which can offset the glucose-lowering effect of dapagliflozin-metformin. Patients with diabetes may need intensified therapy while on everolimus.
What this interaction means in plain words
Dapagliflozin-metformin and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Everolimus belongs to Oncology.
Why it happens
mTOR inhibition causes insulin resistance and reduced pancreatic beta-cell function, opposing antidiabetic effects.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during everolimus therapy, and increase antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Everolimus?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus commonly causes hyperglycemia and dyslipidemia, which can offset the glucose-lowering effect of dapagliflozin-metformin. Patients with diabetes may need intensified therapy while on everolimus.
How serious is the interaction between Dapagliflozin-metformin and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during everolimus therapy, and increase antidiabetic treatment as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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