Drug interactions
Dapagliflozin-metformin + Hydrochlorothiazide
Severity: Moderate
Dapagliflozin-metformin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and blunt the effect of antidiabetic drugs. Additive diuresis with dapagliflozin may cause volume depletion and hypotension, and renal impairment would raise metformin accumulation risk.
What this interaction means in plain words
Dapagliflozin-metformin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides cause hypokalemia-related impaired insulin secretion and insulin resistance, and add to the diuretic effect of dapagliflozin; competition for renal tubular secretion may slightly raise metformin levels.
What to do
Monitor blood glucose, blood pressure, electrolytes and renal function; adjust antidiabetic therapy as needed and watch for volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Dapagliflozin-metformin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and blunt the effect of antidiabetic drugs. Additive diuresis with dapagliflozin may cause volume depletion and hypotension, and renal impairment would raise metformin accumulation risk.
How serious is the interaction between Dapagliflozin-metformin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure, electrolytes and renal function; adjust antidiabetic therapy as needed and watch for volume depletion.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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