Drug interactions
Dapagliflozin-metformin + Lopinavir
Severity: Moderate
Dapagliflozin-metformin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted lopinavir can cause insulin resistance and hyperglycemia, which may blunt the effect of metformin and dapagliflozin. Glycemic control can deteriorate during therapy.
What this interaction means in plain words
Dapagliflozin-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose uptake.
What to do
Monitor glucose and HbA1c after starting lopinavir and intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Lopinavir?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted lopinavir can cause insulin resistance and hyperglycemia, which may blunt the effect of metformin and dapagliflozin. Glycemic control can deteriorate during therapy.
How serious is the interaction between Dapagliflozin-metformin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting lopinavir and intensify antidiabetic therapy if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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