Drug interactions
Dapagliflozin-metformin + Methamphetamine
Severity: Minor
Dapagliflozin-metformin and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sympathomimetic stimulants like methamphetamine can raise blood glucose through adrenergic effects, so glycemic control may deteriorate. Reduced appetite and erratic intake may also make glucose unpredictable, and stopping the stimulant may lead to lower glucose.
What this interaction means in plain words
Dapagliflozin-metformin and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Methamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism via catecholamine-mediated glycogenolysis and reduced insulin sensitivity.
What to do
Monitor blood glucose when starting or stopping methamphetamine and adjust antidiabetic therapy accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Methamphetamine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sympathomimetic stimulants like methamphetamine can raise blood glucose through adrenergic effects, so glycemic control may deteriorate. Reduced appetite and erratic intake may also make glucose unpredictable, and stopping the stimulant may lead to lower glucose.
How serious is the interaction between Dapagliflozin-metformin and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping methamphetamine and adjust antidiabetic therapy accordingly.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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