Drug interactions
Dapagliflozin-metformin + Methylprednisolone
Severity: Moderate
Dapagliflozin-metformin and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic methylprednisolone commonly raises blood glucose and can reduce the effectiveness of metformin and dapagliflozin. The effect depends on dose and duration.
What this interaction means in plain words
Dapagliflozin-metformin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Methylprednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and induce peripheral insulin resistance, opposing the glucose-lowering effect.
What to do
Monitor blood glucose during systemic corticosteroid therapy and adjust antidiabetic doses; reassess when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Methylprednisolone?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic methylprednisolone commonly raises blood glucose and can reduce the effectiveness of metformin and dapagliflozin. The effect depends on dose and duration.
How serious is the interaction between Dapagliflozin-metformin and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during systemic corticosteroid therapy and adjust antidiabetic doses; reassess when the steroid is tapered.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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