Drug interactions
Dapagliflozin-metformin + Midodrine
Severity: Minor
Dapagliflozin-metformin and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine's active metabolite is secreted by renal tubular cationic transporters and may compete with metformin. A clinically meaningful change in exposure is not well documented.
What this interaction means in plain words
Dapagliflozin-metformin and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Midodrine belongs to Miscellaneous.
Why it happens
Possible competition for renal tubular cationic transport (OCT2/MATE) reduces clearance of either drug.
What to do
No routine adjustment needed; monitor renal function and glycemic response if both are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Midodrine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midodrine's active metabolite is secreted by renal tubular cationic transporters and may compete with metformin. A clinically meaningful change in exposure is not well documented.
How serious is the interaction between Dapagliflozin-metformin and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor renal function and glycemic response if both are used long term.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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