Drug interactions
Dapagliflozin-metformin + Ondansetron
Severity: Minor
Dapagliflozin-metformin and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron may increase metformin exposure by inhibiting renal and hepatic transporters involved in its elimination. Higher metformin levels may increase the likelihood of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Dapagliflozin-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of organic cation transporters and MATE transporters reduces renal tubular secretion of metformin.
What to do
No routine change is needed for short-term use; monitor for metformin adverse effects and glycemic response, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Ondansetron?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ondansetron may increase metformin exposure by inhibiting renal and hepatic transporters involved in its elimination. Higher metformin levels may increase the likelihood of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Dapagliflozin-metformin and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for short-term use; monitor for metformin adverse effects and glycemic response, especially in renal impairment.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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