Drug interactions
Dapagliflozin-metformin + Ranolazine
Severity: Moderate
Dapagliflozin-metformin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits renal organic cation transporters and raises metformin plasma concentrations. Higher exposure increases the risk of gastrointestinal effects and lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Dapagliflozin-metformin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Inhibition of OCT2 and MATE1 reduces renal tubular secretion of metformin.
What to do
Limit metformin to the labeled maximum daily dose when used with ranolazine 1000 mg twice daily. Monitor renal function and glycemic control and watch for lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Ranolazine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits renal organic cation transporters and raises metformin plasma concentrations. Higher exposure increases the risk of gastrointestinal effects and lactic acidosis, especially with renal impairment.
How serious is the interaction between Dapagliflozin-metformin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit metformin to the labeled maximum daily dose when used with ranolazine 1000 mg twice daily. Monitor renal function and glycemic control and watch for lactic acidosis.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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