Drug interactions
Dapagliflozin-metformin + Risperidone
Severity: Moderate
Dapagliflozin-metformin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause weight gain and hyperglycaemia, which may reduce the effectiveness of dapagliflozin-metformin. The effect varies between patients and is generally smaller than with some other atypical antipsychotics.
What this interaction means in plain words
Dapagliflozin-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics can reduce insulin sensitivity and promote weight gain, opposing antidiabetic effects (pharmacodynamic antagonism).
What to do
Monitor glucose and HbA1c at baseline and regularly during risperidone therapy. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Risperidone?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause weight gain and hyperglycaemia, which may reduce the effectiveness of dapagliflozin-metformin. The effect varies between patients and is generally smaller than with some other atypical antipsychotics.
How serious is the interaction between Dapagliflozin-metformin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c at baseline and regularly during risperidone therapy. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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