Drug interactions
Daprodustat + Teriflunomide
Severity: Moderate
Daprodustat and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide weakly to moderately inhibits CYP2C8, which metabolizes daprodustat. Daprodustat exposure may rise, increasing the risk of excessive erythropoiesis and thrombotic events.
What this interaction means in plain words
Daprodustat and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8-mediated metabolism of daprodustat.
What to do
Reduce the daprodustat starting dose as labeled for CYP2C8 inhibitors and monitor hemoglobin, adjusting the dose when teriflunomide is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Teriflunomide?
MediHelp rates the interaction as moderate. Daprodustat and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide weakly to moderately inhibits CYP2C8, which metabolizes daprodustat. Daprodustat exposure may rise, increasing the risk of excessive erythropoiesis and thrombotic events.
How serious is the interaction between Daprodustat and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the daprodustat starting dose as labeled for CYP2C8 inhibitors and monitor hemoglobin, adjusting the dose when teriflunomide is started or stopped.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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