Drug interactions
Dapsone + Darunavir
Severity: Minor
Dapsone and Darunavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may increase dapsone levels. The clinical effect is probably modest but could increase hematologic toxicity.
What this interaction means in plain words
Dapsone and Darunavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Darunavir belongs to Anti Virals.
Why it happens
Darunavir and its booster inhibit CYP3A4, reducing dapsone metabolism.
What to do
Monitor hemoglobin and methemoglobin-related symptoms. Reduce the dapsone dose if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Dapsone with Darunavir?
MediHelp rates the interaction as minor. Dapsone and Darunavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may increase dapsone levels. The clinical effect is probably modest but could increase hematologic toxicity.
How serious is the interaction between Dapsone and Darunavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and methemoglobin-related symptoms. Reduce the dapsone dose if toxicity is suspected.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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