Drug interactions
Dapsone + Dasatinib
Severity: Minor
Dapsone and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak time-dependent CYP3A4 inhibitor and could slightly raise dapsone levels. Both drugs can cause hematologic toxicity, such as anemia, so combined effects on blood counts matter more than the kinetic change.
What this interaction means in plain words
Dapsone and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Dasatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by dasatinib reduces dapsone metabolism, plus overlapping hematologic toxicity.
What to do
Monitor complete blood count, including hemoglobin, during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dapsone with Dasatinib?
MediHelp rates the interaction as minor. Dapsone and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak time-dependent CYP3A4 inhibitor and could slightly raise dapsone levels. Both drugs can cause hematologic toxicity, such as anemia, so combined effects on blood counts matter more than the kinetic change.
How serious is the interaction between Dapsone and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count, including hemoglobin, during combined use.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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