Drug interactions
Dapsone + Dronedarone
Severity: Moderate
Dapsone and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and may increase dapsone concentrations. Higher dapsone exposure raises the risk of dose-related hemolysis and methemoglobinemia.
What this interaction means in plain words
Dapsone and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Dronedarone belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by dronedarone reduces dapsone clearance.
What to do
Monitor hemoglobin and methemoglobin-related symptoms such as cyanosis or dyspnea, and lower the dapsone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dapsone with Dronedarone?
MediHelp rates the interaction as moderate. Dapsone and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and may increase dapsone concentrations. Higher dapsone exposure raises the risk of dose-related hemolysis and methemoglobinemia.
How serious is the interaction between Dapsone and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and methemoglobin-related symptoms such as cyanosis or dyspnea, and lower the dapsone dose if toxicity appears.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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