Drug interactions
Dapsone + Fosaprepitant
Severity: Minor
Dapsone and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but after a single dose any increase in dapsone exposure is expected to be small and transient.
What this interaction means in plain words
Dapsone and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant transiently inhibits CYP3A4, slightly reducing dapsone clearance.
What to do
No dose adjustment is generally needed. Monitor for dapsone adverse effects if repeated dosing occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Dapsone with Fosaprepitant?
MediHelp rates the interaction as minor. Dapsone and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but after a single dose any increase in dapsone exposure is expected to be small and transient.
How serious is the interaction between Dapsone and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for dapsone adverse effects if repeated dosing occurs.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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