Drug interactions
Dapsone + Iloperidone
Severity: Minor
Dapsone and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A inhibitor and may modestly raise dapsone levels. Clinical impact is probably small but dose-related toxicity is possible.
What this interaction means in plain words
Dapsone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Iloperidone belongs to Central Nervous System.
Why it happens
Iloperidone inhibits CYP3A4 and may slightly reduce dapsone metabolism.
What to do
Monitor for signs of methemoglobinemia or hemolysis; no empiric dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dapsone with Iloperidone?
MediHelp rates the interaction as minor. Dapsone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak time-dependent CYP3A inhibitor and may modestly raise dapsone levels. Clinical impact is probably small but dose-related toxicity is possible.
How serious is the interaction between Dapsone and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of methemoglobinemia or hemolysis; no empiric dose change is usually required.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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