Drug interactions
Dapsone + Peginterferon alfa 2b
Severity: Moderate
Dapsone and Peginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b can reduce CYP-mediated metabolism of some drugs, but dapsone is metabolised mainly by CYP3A4 and N-acetylation. Both can cause haematological toxicity, so additive anaemia is the more relevant concern.
What this interaction means in plain words
Dapsone and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Additive haematologic toxicity; pharmacokinetic effect on dapsone is not established.
What to do
Monitor haemoglobin and blood counts regularly and reduce or stop dapsone if significant haemolytic anaemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Dapsone with Peginterferon alfa 2b?
MediHelp rates the interaction as moderate. Dapsone and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peginterferon alfa-2b can reduce CYP-mediated metabolism of some drugs, but dapsone is metabolised mainly by CYP3A4 and N-acetylation. Both can cause haematological toxicity, so additive anaemia is the more relevant concern.
How serious is the interaction between Dapsone and Peginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor haemoglobin and blood counts regularly and reduce or stop dapsone if significant haemolytic anaemia develops.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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