Drug interactions
Daridorexant + Dronedarone
Severity: Moderate
Daridorexant and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase daridorexant exposure and cause more next-day somnolence and impaired alertness.
What this interaction means in plain words
Daridorexant and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Dronedarone belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition reduces daridorexant metabolism.
What to do
Limit daridorexant to 25 mg per night with dronedarone. Counsel on daytime drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Dronedarone?
MediHelp rates the interaction as moderate. Daridorexant and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase daridorexant exposure and cause more next-day somnolence and impaired alertness.
How serious is the interaction between Daridorexant and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to 25 mg per night with dronedarone. Counsel on daytime drowsiness and driving.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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