Drug interactions
Daridorexant + Entacapone
Severity: Minor
Daridorexant and Entacapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is cleared mainly by CYP3A4, and strong or moderate inhibitors increase exposure and next-day somnolence. Entacapone is not an established CYP3A4 inhibitor, and any added sedation is likely small.
What this interaction means in plain words
Daridorexant and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daridorexant belongs to Central Nervous System; Entacapone belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 inhibition and additive CNS depression.
What to do
Start daridorexant at the lowest dose and monitor for daytime sleepiness and impaired psychomotor performance. Advise against driving if drowsy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Entacapone?
MediHelp rates the interaction as minor. Daridorexant and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daridorexant is cleared mainly by CYP3A4, and strong or moderate inhibitors increase exposure and next-day somnolence. Entacapone is not an established CYP3A4 inhibitor, and any added sedation is likely small.
How serious is the interaction between Daridorexant and Entacapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start daridorexant at the lowest dose and monitor for daytime sleepiness and impaired psychomotor performance. Advise against driving if drowsy.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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