Drug interactions
Daridorexant + Flibanserin
Severity: Moderate
Daridorexant and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause somnolence and can impair next-day alertness. Taken together, psychomotor impairment and daytime sedation may be greater.
What this interaction means in plain words
Daridorexant and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depressant effects.
What to do
Counsel on daytime impairment and driving; use the lowest effective daridorexant dose and monitor for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Flibanserin?
MediHelp rates the interaction as moderate. Daridorexant and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause somnolence and can impair next-day alertness. Taken together, psychomotor impairment and daytime sedation may be greater.
How serious is the interaction between Daridorexant and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on daytime impairment and driving; use the lowest effective daridorexant dose and monitor for sedation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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