Drug interactions
Daridorexant + Hydroxyzine
Severity: Moderate
Daridorexant and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is strongly sedating, so with daridorexant it can increase drowsiness and impair next-day alertness and psychomotor performance. Older patients are at particular risk of falls.
What this interaction means in plain words
Daridorexant and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-antihistamine and orexin receptor antagonist effects.
What to do
Avoid combining where possible; if both are required, consider a lower daridorexant dose and counsel about driving and daytime impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Hydroxyzine?
MediHelp rates the interaction as moderate. Daridorexant and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is strongly sedating, so with daridorexant it can increase drowsiness and impair next-day alertness and psychomotor performance. Older patients are at particular risk of falls.
How serious is the interaction between Daridorexant and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are required, consider a lower daridorexant dose and counsel about driving and daytime impairment.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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