Drug interactions
Daridorexant + Lurasidone
Severity: Moderate
Daridorexant and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and combined use may add to somnolence and impair psychomotor performance the next day.
What this interaction means in plain words
Daridorexant and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective daridorexant dose and counsel about next-day drowsiness and driving. Monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Lurasidone?
MediHelp rates the interaction as moderate. Daridorexant and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and combined use may add to somnolence and impair psychomotor performance the next day.
How serious is the interaction between Daridorexant and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel about next-day drowsiness and driving. Monitor for excess sedation.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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