Drug interactions
Daridorexant + Meperidine
Severity: Moderate
Daridorexant and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so together they can cause additive sedation and impaired psychomotor performance. This may lead to next-day impairment, falls and a higher risk of accidents.
What this interaction means in plain words
Daridorexant and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression via opioid receptor agonism and orexin receptor antagonism.
What to do
Use the lowest effective dose of each drug and consider reducing the daridorexant dose. Warn patients about daytime drowsiness and impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Meperidine?
MediHelp rates the interaction as moderate. Daridorexant and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so together they can cause additive sedation and impaired psychomotor performance. This may lead to next-day impairment, falls and a higher risk of accidents.
How serious is the interaction between Daridorexant and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and consider reducing the daridorexant dose. Warn patients about daytime drowsiness and impaired driving.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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