Drug interactions
Darunavir + Edoxaban
Severity: Major
Darunavir and Edoxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir (usually boosted with ritonavir or cobicistat) inhibits P-glycoprotein and may raise edoxaban concentrations, increasing bleeding risk. The magnitude is predicted rather than precisely characterized for this specific pair.
What this interaction means in plain words
Darunavir and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Edoxaban belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux of edoxaban, with possible additional boosting-agent effects, increases edoxaban exposure.
What to do
Consider an alternative anticoagulant or antiretroviral where possible. If combined, monitor closely for bleeding and consider the reduced edoxaban dose used for DVT/PE.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Edoxaban?
MediHelp rates the interaction as major. Darunavir and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir (usually boosted with ritonavir or cobicistat) inhibits P-glycoprotein and may raise edoxaban concentrations, increasing bleeding risk. The magnitude is predicted rather than precisely characterized for this specific pair.
How serious is the interaction between Darunavir and Edoxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative anticoagulant or antiretroviral where possible. If combined, monitor closely for bleeding and consider the reduced edoxaban dose used for DVT/PE.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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