Drug interactions
Darunavir + Etonogestrel
Severity: Moderate
Darunavir and Etonogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir- or cobicistat-boosted darunavir may alter progestin exposure through CYP3A4 inhibition, and boosters can also have inducing effects on other pathways. Contraceptive efficacy with the implant is generally maintained but data are limited.
What this interaction means in plain words
Darunavir and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Etonogestrel belongs to Endocrine.
Why it happens
CYP3A4 inhibition by boosted darunavir may increase etonogestrel concentrations.
What to do
Monitor for progestin adverse effects and counsel on adding condoms for HIV and STI prevention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Etonogestrel?
MediHelp rates the interaction as moderate. Darunavir and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir- or cobicistat-boosted darunavir may alter progestin exposure through CYP3A4 inhibition, and boosters can also have inducing effects on other pathways. Contraceptive efficacy with the implant is generally maintained but data are limited.
How serious is the interaction between Darunavir and Etonogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestin adverse effects and counsel on adding condoms for HIV and STI prevention.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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