Drug interactions
Darunavir + Etravirine
Severity: Moderate
Darunavir and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir with ritonavir is an accepted partner of etravirine, but without a booster darunavir levels fall. This can lead to reduced antiviral activity and resistance.
What this interaction means in plain words
Darunavir and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, lowering unboosted darunavir levels; ritonavir boosting compensates.
What to do
Use darunavir only with ritonavir when given with etravirine. Avoid unboosted darunavir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Etravirine?
MediHelp rates the interaction as moderate. Darunavir and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir with ritonavir is an accepted partner of etravirine, but without a booster darunavir levels fall. This can lead to reduced antiviral activity and resistance.
How serious is the interaction between Darunavir and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use darunavir only with ritonavir when given with etravirine. Avoid unboosted darunavir.
What other medicines interact with Etravirine?
MediHelp also lists interactions of Etravirine with, for example, Efavirenz, Isavuconazole, Amobarbital. The full list is on the Etravirine page.
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