Drug interactions
Darunavir + Fluconazole
Severity: Minor
Darunavir and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may modestly increase darunavir exposure through CYP3A4 inhibition. Darunavir is usually boosted with ritonavir or cobicistat, so the added effect is generally limited.
What this interaction means in plain words
Darunavir and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 metabolism of darunavir by fluconazole.
What to do
No dose adjustment is usually required. Monitor for darunavir adverse effects such as rash, diarrhea and liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Fluconazole?
MediHelp rates the interaction as minor. Darunavir and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may modestly increase darunavir exposure through CYP3A4 inhibition. Darunavir is usually boosted with ritonavir or cobicistat, so the added effect is generally limited.
How serious is the interaction between Darunavir and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for darunavir adverse effects such as rash, diarrhea and liver enzyme elevation.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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