Drug interactions
Darunavir + Fluvoxamine
Severity: Minor
Darunavir and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is a CYP3A4 substrate, but fluvoxamine inhibits this enzyme only weakly, so changes in darunavir exposure are expected to be small. Darunavir is usually boosted with ritonavir or cobicistat, which may in turn raise fluvoxamine exposure.
What this interaction means in plain words
Darunavir and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Fluvoxamine belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by fluvoxamine could slightly reduce darunavir clearance.
What to do
No routine dose changes are needed; monitor for adverse effects of both drugs, particularly when a pharmacokinetic booster is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Fluvoxamine?
MediHelp rates the interaction as minor. Darunavir and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir is a CYP3A4 substrate, but fluvoxamine inhibits this enzyme only weakly, so changes in darunavir exposure are expected to be small. Darunavir is usually boosted with ritonavir or cobicistat, which may in turn raise fluvoxamine exposure.
How serious is the interaction between Darunavir and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose changes are needed; monitor for adverse effects of both drugs, particularly when a pharmacokinetic booster is used.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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