Drug interactions
Darunavir + Itraconazole
Severity: Moderate
Darunavir and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, and itraconazole are both CYP3A4 substrates and inhibitors, so each can raise the other's concentrations. Higher itraconazole exposure increases the risk of its adverse effects, including negative inotropy, edema and hepatotoxicity.
What this interaction means in plain words
Darunavir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Itraconazole belongs to Anti Fungals.
Why it happens
Mutual inhibition of CYP3A4-mediated metabolism, with additional strong inhibition from the ritonavir or cobicistat booster.
What to do
Limit itraconazole to no more than 200 mg/day with ritonavir-boosted darunavir. Monitor for itraconazole toxicity and consider measuring itraconazole levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Itraconazole?
MediHelp rates the interaction as moderate. Darunavir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, and itraconazole are both CYP3A4 substrates and inhibitors, so each can raise the other's concentrations. Higher itraconazole exposure increases the risk of its adverse effects, including negative inotropy, edema and hepatotoxicity.
How serious is the interaction between Darunavir and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit itraconazole to no more than 200 mg/day with ritonavir-boosted darunavir. Monitor for itraconazole toxicity and consider measuring itraconazole levels.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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