Drug interactions
Darunavir + Losartan
Severity: Minor
Darunavir and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a pharmacokinetic booster, inhibits CYP3A4 and may alter losartan exposure. Losartan is converted to its active metabolite mainly by CYP2C9 and CYP3A4, so the net effect on antihypertensive activity is uncertain and likely modest.
What this interaction means in plain words
Darunavir and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Losartan belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of losartan, which may change formation of its active metabolite E-3174.
What to do
No empirical dose change is needed. Monitor blood pressure after starting or stopping the antiretroviral regimen and adjust the losartan dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Losartan?
MediHelp rates the interaction as minor. Darunavir and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually given with a pharmacokinetic booster, inhibits CYP3A4 and may alter losartan exposure. Losartan is converted to its active metabolite mainly by CYP2C9 and CYP3A4, so the net effect on antihypertensive activity is uncertain and likely modest.
How serious is the interaction between Darunavir and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor blood pressure after starting or stopping the antiretroviral regimen and adjust the losartan dose to response.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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