Drug interactions
Darunavir + Pravastatin
Severity: Moderate
Darunavir and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, can increase pravastatin exposure, with greater effect in some studies when boosted. Higher statin levels can increase the risk of myopathy. The interaction is generally manageable with dose limitation.
What this interaction means in plain words
Darunavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Pravastatin belongs to Cardiovascular.
Why it happens
Likely inhibition of hepatic uptake transporters such as OATP1B1 by the boosted protease inhibitor regimen; pravastatin has minimal CYP3A4 metabolism.
What to do
Begin with the lowest pravastatin dose and titrate to lipid response. Monitor for muscle pain, weakness and CK elevation if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Pravastatin?
MediHelp rates the interaction as moderate. Darunavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, can increase pravastatin exposure, with greater effect in some studies when boosted. Higher statin levels can increase the risk of myopathy. The interaction is generally manageable with dose limitation.
How serious is the interaction between Darunavir and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with the lowest pravastatin dose and titrate to lipid response. Monitor for muscle pain, weakness and CK elevation if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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