Drug interactions
Darunavir + Rimegepant
Severity: Major
Darunavir and Rimegepant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and P-glycoprotein and can raise rimegepant exposure. This increases the risk of adverse effects.
What this interaction means in plain words
Darunavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces rimegepant clearance.
What to do
Avoid concomitant use. Use another acute migraine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rimegepant
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Rimegepant?
MediHelp rates the interaction as major. Darunavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and P-glycoprotein and can raise rimegepant exposure. This increases the risk of adverse effects.
How serious is the interaction between Darunavir and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. Use another acute migraine therapy.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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