Drug interactions
Darunavir + Rosiglitazone
Severity: Moderate
Darunavir and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can induce insulin resistance and hyperglycemia, which may counteract the glycemic benefit of rosiglitazone. Darunavir (usually boosted with ritonavir) carries a lower metabolic risk than older agents, but glucose control can still worsen.
What this interaction means in plain words
Darunavir and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-associated insulin resistance.
What to do
Monitor fasting glucose and HbA1c after starting or changing antiretroviral therapy. Intensify antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Rosiglitazone?
MediHelp rates the interaction as moderate. Darunavir and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can induce insulin resistance and hyperglycemia, which may counteract the glycemic benefit of rosiglitazone. Darunavir (usually boosted with ritonavir) carries a lower metabolic risk than older agents, but glucose control can still worsen.
How serious is the interaction between Darunavir and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing antiretroviral therapy. Intensify antidiabetic therapy if control deteriorates.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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