Drug interactions
Darunavir + Voriconazole
Severity: Moderate
Darunavir and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, can alter voriconazole exposure; ritonavir lowers voriconazole levels through CYP2C19 induction, while darunavir and voriconazole may also raise each other via CYP3A4. The net effect is unpredictable and may cause subtherapeutic antifungal levels or toxicity.
What this interaction means in plain words
Darunavir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Mixed CYP3A4 inhibition and ritonavir-mediated CYP2C19 induction altering voriconazole and darunavir exposure.
What to do
Monitor voriconazole trough concentrations and adjust dose accordingly. Watch for hepatotoxicity, visual effects and QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Voriconazole?
MediHelp rates the interaction as moderate. Darunavir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with ritonavir or cobicistat, can alter voriconazole exposure; ritonavir lowers voriconazole levels through CYP2C19 induction, while darunavir and voriconazole may also raise each other via CYP3A4. The net effect is unpredictable and may cause subtherapeutic antifungal levels or toxicity.
How serious is the interaction between Darunavir and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough concentrations and adjust dose accordingly. Watch for hepatotoxicity, visual effects and QT prolongation.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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