Drug interactions
Dasatinib + Eliglustat
Severity: Moderate
Dasatinib and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have QT-prolonging potential, and eliglustat exposure can rise with CYP3A4 inhibition. Combined use may add to arrhythmia risk.
What this interaction means in plain words
Dasatinib and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Eliglustat belongs to Miscellaneous.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition raising eliglustat exposure.
What to do
Obtain a baseline ECG and monitor it during combined use. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Dasatinib with Eliglustat?
MediHelp rates the interaction as moderate. Dasatinib and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have QT-prolonging potential, and eliglustat exposure can rise with CYP3A4 inhibition. Combined use may add to arrhythmia risk.
How serious is the interaction between Dasatinib and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during combined use. Correct electrolyte abnormalities.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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