Drug interactions
Dasatinib + Eslicarbazepine
Severity: Moderate
Dasatinib and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may lower dasatinib exposure. Reduced exposure may compromise response in leukemia treatment.
What this interaction means in plain words
Dasatinib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by eslicarbazepine increases dasatinib metabolism.
What to do
Monitor hematologic and molecular response; consider an alternative antiseizure drug that is not an enzyme inducer, or dasatinib dose titration under specialist guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Eslicarbazepine?
MediHelp rates the interaction as moderate. Dasatinib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may lower dasatinib exposure. Reduced exposure may compromise response in leukemia treatment.
How serious is the interaction between Dasatinib and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hematologic and molecular response; consider an alternative antiseizure drug that is not an enzyme inducer, or dasatinib dose titration under specialist guidance.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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