Drug interactions
Dasatinib + Etravirine
Severity: Moderate
Dasatinib and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower dasatinib concentrations, risking reduced efficacy. Dasatinib may modestly raise etravirine levels, which is of limited importance.
What this interaction means in plain words
Dasatinib and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, increasing dasatinib clearance.
What to do
Monitor leukemia response and consider a dasatinib dose increase if response is inadequate. Consider an alternative antiretroviral if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Dasatinib with Etravirine?
MediHelp rates the interaction as moderate. Dasatinib and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower dasatinib concentrations, risking reduced efficacy. Dasatinib may modestly raise etravirine levels, which is of limited importance.
How serious is the interaction between Dasatinib and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor leukemia response and consider a dasatinib dose increase if response is inadequate. Consider an alternative antiretroviral if feasible.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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