Drug interactions
Dasatinib + Fluconazole
Severity: Major
Dasatinib and Fluconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase dasatinib concentrations by inhibiting CYP3A4, and both agents have QT-prolonging potential. The result may be greater dasatinib toxicity such as myelosuppression and fluid retention, along with arrhythmia risk.
What this interaction means in plain words
Dasatinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by fluconazole reduces dasatinib clearance, with additive QT prolongation.
What to do
Prefer an alternative antifungal with less CYP3A4 inhibition if possible. If combined, monitor ECG, electrolytes and blood counts and consider reducing the dasatinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Fluconazole?
MediHelp rates the interaction as major. Dasatinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole can increase dasatinib concentrations by inhibiting CYP3A4, and both agents have QT-prolonging potential. The result may be greater dasatinib toxicity such as myelosuppression and fluid retention, along with arrhythmia risk.
How serious is the interaction between Dasatinib and Fluconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antifungal with less CYP3A4 inhibition if possible. If combined, monitor ECG, electrolytes and blood counts and consider reducing the dasatinib dose.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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