Drug interactions
Dasatinib + Fluphenazine
Severity: Moderate
Dasatinib and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may raise the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is higher with electrolyte disturbances, heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Dasatinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through effects on cardiac potassium channels.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining, then repeat ECG monitoring during therapy. Consider an alternative antipsychotic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Fluphenazine?
MediHelp rates the interaction as moderate. Dasatinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may raise the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is higher with electrolyte disturbances, heart disease or other QT-prolonging drugs.
How serious is the interaction between Dasatinib and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining, then repeat ECG monitoring during therapy. Consider an alternative antipsychotic if the QTc becomes markedly prolonged.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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