Drug interactions
Dasatinib + Fluvoxamine
Severity: Moderate
Dasatinib and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmias including torsades de pointes. Dasatinib is also a CYP3A4 substrate, and fluvoxamine is a weak CYP3A4 inhibitor, so exposure to dasatinib may rise modestly.
What this interaction means in plain words
Dasatinib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 inhibition by fluvoxamine raising dasatinib exposure.
What to do
Obtain a baseline ECG and monitor the QTc during combined therapy, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant with less QT effect if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Fluvoxamine?
MediHelp rates the interaction as moderate. Dasatinib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmias including torsades de pointes. Dasatinib is also a CYP3A4 substrate, and fluvoxamine is a weak CYP3A4 inhibitor, so exposure to dasatinib may rise modestly.
How serious is the interaction between Dasatinib and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during combined therapy, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant with less QT effect if the QTc becomes prolonged.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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