Drug interactions
Dasatinib + Fosaprepitant
Severity: Moderate
Dasatinib and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and may raise dasatinib levels during short courses. Clinical impact is usually limited by the brief duration of use.
What this interaction means in plain words
Dasatinib and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant temporarily inhibits CYP3A4, reducing dasatinib clearance.
What to do
Monitor for dasatinib adverse effects such as cytopenias and fluid retention in the days after fosaprepitant. No routine dose change is needed for single doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Dasatinib with Fosaprepitant?
MediHelp rates the interaction as moderate. Dasatinib and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and may raise dasatinib levels during short courses. Clinical impact is usually limited by the brief duration of use.
How serious is the interaction between Dasatinib and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dasatinib adverse effects such as cytopenias and fluid retention in the days after fosaprepitant. No routine dose change is needed for single doses.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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