Drug interactions
Dasatinib + Gilteritinib
Severity: Major
Dasatinib and Gilteritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combined use raises the risk of torsades de pointes. Patients with electrolyte abnormalities, bradycardia or structural heart disease are at higher risk.
What this interaction means in plain words
Dasatinib and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Gilteritinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform ECG at baseline and regularly during treatment, and correct potassium and magnesium. Reduce or interrupt a drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Dasatinib with Gilteritinib?
MediHelp rates the interaction as major. Dasatinib and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so combined use raises the risk of torsades de pointes. Patients with electrolyte abnormalities, bradycardia or structural heart disease are at higher risk.
How serious is the interaction between Dasatinib and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG at baseline and regularly during treatment, and correct potassium and magnesium. Reduce or interrupt a drug if QTc becomes markedly prolonged.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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