Drug interactions
Dasatinib + Granisetron
Severity: Moderate
Dasatinib and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may add to the risk of ventricular arrhythmia, including torsades de pointes. The risk is greater with electrolyte disturbances or existing cardiac disease.
What this interaction means in plain words
Dasatinib and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarization through effects on cardiac potassium channels.
What to do
Correct potassium and magnesium before and during therapy, and obtain a baseline ECG with repeat monitoring of the QTc. Consider a non-QT-prolonging antiemetic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Granisetron?
MediHelp rates the interaction as moderate. Dasatinib and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so giving them together may add to the risk of ventricular arrhythmia, including torsades de pointes. The risk is greater with electrolyte disturbances or existing cardiac disease.
How serious is the interaction between Dasatinib and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during therapy, and obtain a baseline ECG with repeat monitoring of the QTc. Consider a non-QT-prolonging antiemetic if the QTc becomes markedly prolonged.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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