Drug interactions
Dasatinib + Iloperidone
Severity: Major
Dasatinib and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QTc interval, and each may raise the other's levels via CYP3A4 inhibition. Together this can increase the risk of arrhythmia and of concentration-related adverse effects.
What this interaction means in plain words
Dasatinib and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus mutual CYP3A4 inhibition, with iloperidone also being a CYP3A4 substrate.
What to do
Avoid the combination if possible; otherwise monitor ECG and electrolytes closely and watch for dasatinib toxicity and iloperidone adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dasatinib with Iloperidone?
MediHelp rates the interaction as major. Dasatinib and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QTc interval, and each may raise the other's levels via CYP3A4 inhibition. Together this can increase the risk of arrhythmia and of concentration-related adverse effects.
How serious is the interaction between Dasatinib and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor ECG and electrolytes closely and watch for dasatinib toxicity and iloperidone adverse effects.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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