Drug interactions
Dasatinib + Midazolam
Severity: Moderate
Dasatinib and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak time-dependent CYP3A4 inhibitor and can modestly increase exposure to sensitive CYP3A4 substrates such as midazolam. This may lengthen or deepen sedation, mainly with oral midazolam.
What this interaction means in plain words
Dasatinib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by dasatinib reduces midazolam metabolism.
What to do
Use the lowest effective midazolam dose, particularly oral, and monitor sedation and respiration. Extend observation after procedural sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Midazolam?
MediHelp rates the interaction as moderate. Dasatinib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak time-dependent CYP3A4 inhibitor and can modestly increase exposure to sensitive CYP3A4 substrates such as midazolam. This may lengthen or deepen sedation, mainly with oral midazolam.
How serious is the interaction between Dasatinib and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose, particularly oral, and monitor sedation and respiration. Extend observation after procedural sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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