Drug interactions
Dasatinib + Nisoldipine
Severity: Moderate
Dasatinib and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and may raise exposure to nisoldipine, a sensitive CYP3A4 substrate with high first-pass metabolism. This can cause excess hypotension, edema and dizziness.
What this interaction means in plain words
Dasatinib and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Nisoldipine belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and hepatic CYP3A4 metabolism of nisoldipine.
What to do
Monitor blood pressure and edema and reduce the nisoldipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Dasatinib with Nisoldipine?
MediHelp rates the interaction as moderate. Dasatinib and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak CYP3A4 inhibitor and may raise exposure to nisoldipine, a sensitive CYP3A4 substrate with high first-pass metabolism. This can cause excess hypotension, edema and dizziness.
How serious is the interaction between Dasatinib and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and reduce the nisoldipine dose if hypotension occurs.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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