Drug interactions
Dasatinib + Omeprazole
Severity: Major
Dasatinib and Omeprazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib absorption depends on an acidic stomach, and omeprazole can substantially lower its exposure. This may reduce the efficacy of leukemia treatment.
What this interaction means in plain words
Dasatinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH reduces dasatinib solubility and absorption.
What to do
Avoid PPIs; use a short-acting antacid taken at least 2 hours before or after dasatinib, or consider an H2 blocker only with careful timing, and monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Omeprazole?
MediHelp rates the interaction as major. Dasatinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on an acidic stomach, and omeprazole can substantially lower its exposure. This may reduce the efficacy of leukemia treatment.
How serious is the interaction between Dasatinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs; use a short-acting antacid taken at least 2 hours before or after dasatinib, or consider an H2 blocker only with careful timing, and monitor response.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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